黄连素抑制人乳腺癌细胞MCF-7作用的研究

被引：6

作者：

杨艳红 ^{[1
]}

张娜 ^{[2
]}

江殷 ^{[3
]}

黎昆东 ^{[2
]}

尤琪 ^{[2
]}

陈娟 ^{[2
]}

张巨峰 ^{[2
]}

机构：

[1] 广东药科大学附属第一医院(临床医学院)

[2] 广东药科大学生命科学与生物制药学院

[3] 上海市大华医院

来源：

广东药科大学学报 | 2017年 / 33卷 / 03期

基金：

广东省科技计划;

关键词：

黄连素; 乳腺癌细胞; 增殖; 凋亡;

D O I：

10.16809/j.cnki.2096-3653.2017032001

中图分类号：

R285 [中药药理学];

学科分类号：

100806 [中药药理学];

摘要：

目的研究黄连素对人乳腺癌细胞MCF-7的抑制作用。方法用WST-1方法、流式细胞术和划痕实验分别检测黄连素对乳腺癌细胞MCF-7增殖、凋亡、细胞周期及迁移能力的影响。结果不同浓度的黄连素可以抑制乳腺癌细胞MCF-7的增殖。黄连素作用于MCF-7细胞24 h可以使细胞周期阻滞在G1期,进入S期的细胞比例降低,同时MCF-7细胞凋亡明显增加。黄连素作用于MCF-7细胞24 h及48 h后,可以抑制MCF-7细胞的迁移能力。结论黄连素可有效地抑制乳腺癌细胞的增殖与迁移能力,并诱导其凋亡,参与抗肿瘤作用。

引用

页码：361 / 365

页数：5

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