药物性肝损伤发病机制研究进展

被引:51
作者
明雅南
刘晓琳
茅益民
机构
[1] 上海交通大学医学院附属仁济医院 上海市消化疾病研究所
关键词
药物性肝损伤; 发病机制; 线粒体功能损伤;
D O I
暂无
中图分类号
R575 [肝及胆疾病];
学科分类号
100201 [内科学];
摘要
药物的肝脏毒性是欧美国家导致急性肝衰竭的重要原因。Kaplowitz提出的以特异性"上游"事件和非特异性"下游"事件为基础的DILI(Drug induced liver injury,DILI)发病机制,为进一步开展DILI机制的研究提供了明确的方向。目前已知,DILI的发生机制复杂,涉及药物代谢、线粒体功能损伤、免疫反应、信号转导、遗传和环境等多个方面。DILI的发生和进展可能是多重因素综合作用的结果。
引用
收藏
页码:657 / 660
页数:4
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