COMT抑制剂治疗帕金森病的新进展

被引:4
作者
于宝成
王鲁宁
机构
[1] 解放军白求恩国际和平医院,解放军总医院,石家庄,,北京,
关键词
帕金森病; 左旋多巴; 抑制剂; 运动障碍;
D O I
暂无
中图分类号
R742.5 [震颤麻痹综合征];
学科分类号
摘要
<正>自从1969年Cotzias确认口服左旋多巴可治疗帕金森病(震颤麻痹)以来,左旋多巴已成为治疗帕金森病的首选药。1997年3月在伦敦召开的第12届国际帕金森病研讨会上,认为左旋多巴制剂仍然是控制帕金森病的最有效药物。但是用左旋多巴治疗5年后,有50%以上的患者均会出现药效消失、运动波动(“剂末”现象、“开关”现象、“冰冻”现象)等“长期左旋多巴综合征”。左旋多巴控释剂(或缓释剂)虽然能保持血浆左旋多巴水平相对恒定,但其生物利用度比普通制剂低,并且达到血浆峰值时间长,故限制了它的应用。因此寻找
引用
收藏
页码:89 / 91
页数:3
相关论文
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