姜黄素类似物的合成及其清除自由基的研究

被引：16

作者：

邓兵 ^{[1
]}

杜志云 ^{[2
]}

唐煌 ^{[3
]}

古练权 ^{[3
]}

机构：

[1] 达州职业技术学院

[2] 广东工业大学轻工化工学院

[3] 中山大学药学院

来源：

化学研究与应用 | 2006年 / 09期

关键词：

姜黄素类似物; 抗自由基; DPPH; 合成;

D O I：

暂无

中图分类号：

TQ461 [中草药制剂的生产]; R285 [中药药理学];

学科分类号：

1008 ;

摘要：

Curcumin is the main component of Curcuma longa,a traditional Chinese medicinal herb,with excellent antioxidant.Curcumin is easily decomposed under light and heat.In this study,to find stable antioxidants,6 curcumin analogs(A1-6) were synthesized by coupling the appropriate aromatic aldehyde and cyclohexanon with HCl catalysis,and the free radical（DPPH） scavenging abilities of synthetic curcumin analogs were evaluated.The results showed that the free radical（DPPH） scavenging abilities of curcumin analogs（A2,A3 and A6） were promoted when hydroxyl or methoxyl groups were introduced in the ortho place of phenols,the compound with ortho dihydroxy groups showed the stronges free radical（DPPH） scavenging abilities among curcumin analogs with IC50 of 1.5 μM.

引用

页码：1124 / 1126

页数：3