可溶性ST2在急性冠脉综合征患者预后评估中的价值

被引：7

作者：

葛剑力

邵莉

滕丽莉

江华

机构：

[1] 同济大学附属上海市东方医院老年医学科

来源：

中国老年学杂志 | 2014年 / 34卷 / 21期

关键词：

sST2; 超敏TNT; 超敏CRP; pro-BNP; 急性冠脉综合征;

D O I：

暂无

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

100201 [内科学];

摘要：

目的评估可溶性ST2(s ST2)水平对急性冠脉综合征(ACS)患者预后判定的应用价值。方法符合美国心脏病学会(ACC)ACS患者102例,失访2例。测定外周血s ST2、pro-BNP、超敏C反应蛋白(hs-CRP)、超敏肌钙蛋白(TNT)。研究随访6个月,通过门诊或电话随访患者病情变化及心脏事件。结果 1各组间s ST2、pro-BNP水平存在显著性差异(P<0.05,P<0.01)。2s ST2与血糖,总胆固醇(TC)及CK-MB峰值呈正相关,与高密度脂蛋白(HDL)呈负相关。3随访期,心脏事件发生率与s ST2水平正相关。4s ST2检测的敏感性及特异性略优于超敏TNT、hs-CRP及pro-BNP。预测心力衰竭事件、ACS、心血管意外死亡最敏感的生化指标分别是s ST2,超敏TNT,s ST2。结论 ACS患者s ST2水平是预测ACS患者预后的独立指标,不受年龄、肝肾功能、心肌酶谱水平、血糖、血脂、左室射血分数(LVEF)、血白细胞等的影响。综合监测s ST2、超敏TNT,hs-CRP和proBNP,可提高评估ACS预后的敏感性及特异性。

引用

页码：5970 / 5973

页数：4

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