动脉钙化:一种慢性炎症性疾病

被引：20

作者：

吉庆伟 ^{[1
,2
]}

周玉杰 ^{[1
,2
]}

机构：

[1] 首都医科大学附属北京安贞医院

[2] 北京市心肺血管疾病研究所十二病房

来源：

心肺血管病杂志 | 2015年 / 34卷 / 01期

关键词：

动脉钙化; 慢性炎症; 心血管疾病;

D O I：

暂无

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

100201 [内科学];

摘要：

<正>数十年前即已观察到动脉钙化,将其视为与衰老相关的被动现象,是矿物质代谢发生紊乱的一种进行性疾病。血管系统的异位钙化主要累及主动脉、冠状动脉和外周动脉。既往认为动脉钙化是磷酸钙晶体被动沉积于斑块所致,现已明确其发生发展类似于胚胎骨形成的主动调节过程[1-2]。动脉钙化和动脉粥样硬化具有相同的危险因素包括血脂、年龄、性别、高血压、糖尿病、慢性肾脏疾病以及吸烟,但其发生的细胞和分子机制仍未阐明[3-5]。近年的研究表明,与动脉粥

引用

页码：67 / 69

页数：3

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