非酒精性脂肪性肝病发病机制的研究进展

被引：25

作者：

舒泳翔

吴鹏波

郭芳

袁早送

谭诗云

机构：

[1] 武汉大学人民医院消化内科

来源：

胃肠病学和肝病学杂志 | 2015年 / 24卷 / 08期

关键词：

非酒精性脂肪性肝病; 发病机制; 肠肝轴; 遗传变异;

D O I：

暂无

中图分类号：

R575.5 [肝代谢障碍];

学科分类号：

100201 [内科学];

摘要：

非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)是一种无过量饮酒史,组织学改变与酒精性肝病相类似的临床病理综合征。其病程包括单纯性脂肪肝、脂肪性肝炎(non-alcoholic steatohepatitis,NASH)和脂肪性肝纤维化,最后可能演变成肝硬化和肝癌。其病因与发病机制复杂,尚未完全明了,目前仍以"二次打击"学说为基础,但近年来研究表明肠肝轴、幽门螺杆菌感染、自噬与凋亡、脂肪因子、遗传变异、个人因素等均参与NAFLD的发生发展。本文就上述发病机制的研究进展作一系统回顾。

引用

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页码：901 / 903

页数：3

相关论文

共 18 条

[1]

Autophagy and Non-Alcoholic Fatty Liver Disease.[J].Vanessa J. Lavallard;Philippe Gual;Ana-Maria Cuervo.BioMed Research International.2014,

[2]

Non-alcoholic fatty liver disease, obesity and the metabolic syndrome [J].

Dietrich, Peter ;

Hellerbrand, Claus .

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY, 2014, 28 (04) :637-653

[3]

Characteristics and diagnosis of NAFLD / NASH.[J].Etsuko Hashimoto;Makiko Taniai;Katsutoshi Tokushige.J Gastroenterol Hepatol.2013,

[4]

Lipoprotein Metabolism, Dyslipidemia, and Nonalcoholic Fatty Liver Disease [J].

Cohen, David E. ;

Fisher, Edward A. .

SEMINARS IN LIVER DISEASE, 2013, 33 (04) :380-388

[5]

Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease [J].

Kawano, Yuki ;

Cohen, David E. .

JOURNAL OF GASTROENTEROLOGY, 2013, 48 (04) :434-441

[6]

Focus on emerging drugs for the treatment of patients with non-alcoholic fatty liver disease [J].

Federico, Alessandro ;

Zulli, Claudio ;

de Sio, Ilario ;

Del Prete, Anna ;

Dallio, Marcello ;

Masarone, Mario ;

Loguercio, Carmela .

WORLD JOURNAL OF GASTROENTEROLOGY, 2014, 20 (45) :16841-16857

[7]

Gut-liver axis and probiotics: Their role in non-alcoholic fatty liver disease [J].

Paolella, Giulia ;

Mandato, Claudia ;

Pierri, Luca ;

Poeta, Marco ;

Di Stasi, Martina ;

Vajro, Pietro .

WORLD JOURNAL OF GASTROENTEROLOGY, 2014, 20 (42) :15518-15531

[8]

Histopathology of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis [J].

Takahashi, Yoshihisa ;

Fukusato, Toshio .

WORLD JOURNAL OF GASTROENTEROLOGY, 2014, 20 (42) :15539-15548

[9]

益生菌作用治疗非酒精性脂肪肝 [J].

姚晓敏 ;

曲均革 ;

林爱斌 ;

李宏伟 .

国际药学研究杂志, 2014, 41 (05) :548-551+558

[10]

Role of adipokines and peroxisome proliferator-activated receptors in nonalcoholic fatty liver disease [J].

Giby, Vettickattuparambil George ;

Ajith, Thekkuttuparambil Ananthanarayanan .

WORLD JOURNAL OF HEPATOLOGY, 2014, 6 (08) :570-579