粪便钙卫蛋白与溃疡性结肠炎肠道病变程度及范围的相关性

被引:8
作者
杨荣萍 [1 ]
张金梅 [1 ]
王磊 [2 ]
康文全 [1 ]
郭梅梅 [1 ]
机构
[1] 深圳市南山区人民医院消化内科
[2] 深圳市南山区人民医院中心实验室
关键词
溃疡性结肠炎; 粪便钙卫蛋白; 病变严重程度; 病变范围;
D O I
10.13820/j.cnki.gdyx.2017.02.014
中图分类号
R574.62 [结肠疾病];
学科分类号
100201 [内科学];
摘要
目的探讨钙卫蛋白(FC)水平与溃疡性结肠炎(UC)肠道病变严重程度、病变范围之间的关系。方法 UC患者纳入后行结肠镜检查、抽血及留取粪便标本检测钙卫蛋白。参照UC内镜严重程度指数(UCEIS)对5个结肠肠段进行内镜评分,为评价FC水平与病变严重程度、病变范围之间的关系,应用Spearman相关性分析FC与最高内镜评分(M-UCEIS)、总内镜评分(S-UCEIS)之间关系。结果共有64例UC完成82次结肠镜检查及FC检测。FC水平与M-UCEIS明显相关(r=0.794,P<0.01)。应用ROC曲线分析,鉴别内镜病变中重度的最佳界值510.6 mg/kg,敏感度和特异度分别为71.4%和100.0%。与M-UCEIS相比,FC水平与S-UCEIS强相关(r=0.821,P<0.01)。结论 FC水平与UC肠道黏膜病变范围、病变严重程度相关,可作为结肠镜的非侵入性替代方法。
引用
收藏
页码:247 / 250
页数:4
相关论文
共 5 条
[1]
Reliability and Initial Validation of the Ulcerative Colitis Endoscopic Index of Severity [J].
Travis, Simon P. L. ;
Schnell, Dan ;
Krzeski, Piotr ;
Abreu, Maria T. ;
Altman, Douglas G. ;
Colombel, Jean-Frederic ;
Feagan, Brian G. ;
Hanauer, Stephen B. ;
Lichtenstein, Gary R. ;
Marteau, Philippe R. ;
Reinisch, Walter ;
Sands, Bruce E. ;
Yacyshyn, Bruce R. ;
Schnell, Patrick ;
Bernhardt, Christian A. ;
Mary, Jean-Yves ;
Sandborn, William J. .
GASTROENTEROLOGY, 2013, 145 (05) :987-995
[2]
P135 Fecal calprotectin more accurately reflects endoscopic activity of ulcerative colitis than the Lichtiger Index; CRP or blood leukocytes.[J].A. Schoepfer;C. Beglinger;A. Straumann;E. Safroneeva;Y. Romero;D. Armstrong;C. Schmidt;M. Trummler;V. Pittet;S. Vavricka.Journal of Crohn's and Colitis.2012,
[3]
Endoscopic Evaluation of Crohn's Disease Activity: Comparison of the CDEIS and the SES-CD [J].
Sipponen, Taina ;
Nuutinen, Hannu ;
Turunen, Ulla ;
Farkkila, Martti .
INFLAMMATORY BOWEL DISEASES, 2010, 16 (12) :2131-2136
[4]
Calprotectin and lactoferrin in the assessment of intestinal inflammation and organic disease [J].
D'Inca, Renata ;
Dal Pont, Elisabetta ;
Di Leo, Vincenza ;
Ferronato, Antonio ;
Fries, Walter ;
Vettorato, Maria Grazia ;
Martines, Diego ;
Sturniolo, Giacomo Carlo .
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 2007, 22 (04) :429-437
[5]
Relationship between fecal calprotectin, intestinal inflammation, and peripheral blood neutrophils in patients with active ulcerative colitis [J].
Hanai, H ;
Takeuchi, K ;
Iida, T ;
Kashiwagi, N ;
Saniabadi, AR ;
Matsushita, I ;
Sato, Y ;
Kasuga, N ;
Nakamura, T .
DIGESTIVE DISEASES AND SCIENCES, 2004, 49 (09) :1438-1443