MiR-21与肾脏疾病关系的研究进展

被引：4

作者：

王雪艳

焦军东

机构：

[1] 哈尔滨医科大学附属第二医院肾内科

来源：

中国中西医结合肾病杂志 | 2017年 / 03期

关键词：

肾脏疾病; MiR-21; 肾纤维化; 多囊肾; 肾病; 泌尿系统疾病; 肾脏纤维化; 肾小管; 肾单位; 肾脏病变; 慢性肾脏病; 线粒体; 粒线体;

D O I：

暂无

中图分类号：

R692 [肾疾病];

学科分类号：

摘要：

<正>微小RNA（miRNA）是一组含21～25个核苷酸的非编码RNA,通过转录后调节机制参与机体各个器官的生物学功能,在细胞存活、增殖、分化、凋亡、炎性反应、纤维化等信号通路中扮演重要角色[1]。近年来随着对miRNA的研究,发现其在肾脏疾病中发挥着重要作用,并且miR-21倍受重视,参与急性肾损伤,肾脏纤维化,肾脏肿瘤等,因此miR-21有可能是未来

引用

页码：259 / 261

页数：3

共 14 条

[1] miR-21与胶质瘤的研究进展
李海松
赵刚
[J]. 中国实验诊断学, 2012, 16 (03) : 552 - 555
[2] Transforming growth factor-β-sphingosine kinase 1/S1P signaling upregulates microRNA-21 to promote fibrosis in renal tubular epithelial cells[J] . Xiujuan Liu,Quan Hong,Zhen Wang,Yanyan Yu,Xin Zou,Lihong Xu.Experimental Biology and Medicine . 2016 (3)
[3] Anti-microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways
Gomez, Ivan G.
MacKenna, Deidre A.
Johnson, Bryce G.
Kaimal, Vivek
Roach, Allie M.
Ren, Shuyu
Nakagawa, Naoki
Xin, Cuiyan
Newitt, Rick
Pandya, Shweta
Xia, Tai-He
Liu, Xueqing
Borza, Dorin-Bogdan
Grafals, Monica
Shankland, Stuart J.
Himmelfarb, Jonathan
Portilla, Didier
Liu, Shiguang
Chau, B. Nelson
Duffield, Jeremy S.
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2015, 125 (01) : 141 - 156
[4] Effect of miR-21 on Renal Fibrosis by Regulating MMP-9 and TIMP1 in kk-ay Diabetic Nephropathy Mice
Wang, Jinyang
Gao, Yanbin
Ma, Mingfei
Li, Minzhou
Zou, Dawei
Yang, Jinkui
Zhu, Zhiyao
Zhao, Xuan
[J]. CELL BIOCHEMISTRY AND BIOPHYSICS, 2013, 67 (02) : 537 - 546
[5] miR-21 Contributes to Xenon-conferred Amelioration of Renal Ischemia–Reperfusion Injury in Mice[J] . Ping Jia,Jie Teng,Jianzhou Zou,Yi Fang,Xiaoyan Zhang,Zeljko J. Bosnjak,Mingyu Liang,Xiaoqiang Ding.Anesthesiology . 2013 (3)
[6] miR-21 is a key therapeutic target for renal injury in a mouse model of type 2 diabetes
Zhong, X.
Chung, A. C. K.
Chen, H. Y.
Dong, Y.
Meng, X. M.
Li, R.
Yang, W.
Hou, F. F.
Lan, H. Y.
[J]. DIABETOLOGIA, 2013, 56 (03) : 663 - 674
[7] The Clinical Utility of miR-21 as a Diagnostic and Prognostic Marker for Renal Cell Carcinoma
Faragalla, Hala
Youssef, Youssef M.
Scorilas, Andreas
Khalil, Bishoy
White, Nicole M. A.
Mejia-Guerrero, Salvador
Khella, Heba
Jewett, Michael A. S.
Evans, Andrew
Lichner, Zsuzsanna
Bjarnason, Georg
Sugar, Linda
Attalah, Magdy I.
Yousef, George M.
[J]. JOURNAL OF MOLECULAR DIAGNOSTICS, 2012, 14 (04) : 385 - 392
[8] Cyclic AMP-mediated cyst expansion[J] . Darren P. Wallace.BBA - Molecular Basis of Disease . 2010 (10)
[9] MicroRNAs and the regulation of fibrosis
Jiang, Xiaoying
Tsitsiou, Eleni
Herrick, Sarah E.
Lindsay, Mark A.
[J]. FEBS JOURNAL, 2010, 277 (09) : 2015 - 2021
[10] MicroRNA-21 protects from mesangial cell proliferation induced by diabetic nephropathy in db/db mice
Zhang, Zheng
Peng, Huimin
Chen, Junxia
Chen, Xin
Han, Fei
Xu, Xiaoming
He, Xiaoyan
Yan, Ning
[J]. FEBS LETTERS, 2009, 583 (12): : 2009 - 2014

← 1 2 →