血清tau蛋白对颅内出血患者结局的预测价值

被引:6
作者
程振宇
陈亦华
林小峰
机构
[1] 浙江省金华市人民医院神经外科
关键词
tau蛋白; 脑出血; 预后;
D O I
暂无
中图分类号
R743.34 [脑出血];
学科分类号
摘要
目的研究血清tau蛋白浓度对颅内出血(ICH)预后的预测价值。方法选取2010年12月至2012年12月金华市人民医院神经外科收治的98例急性基底节出血患者(ICH组)和98例同期年龄匹配的健康体检者(对照组)作前瞻性研究。ICH组患者在脑出血后1.0~13.8 h而对照组在入院时即测定血清tau蛋白浓度,分析ICH患者预后的独立危险因素。结果血清tau蛋白浓度与血肿量和美国国立卫生院神经功能缺损(NIHSS)评分呈显著正相关(r=0.620、0.594,P均<0.01),且ICH组患者血清tau蛋白浓度较对照组显著升高(t=19.278,P<0.01)。多变量二分类Logistic回归分析显示,ICH组患者住院期间死亡、三个月死亡及三个月预后不良(改良Rankin评分>2分)的独立危险因素均为NIHSS评分(OR=1.411、1.397、1.286,95%CI=1.110~4.521、1.103~4.224、1.097~3.923)、血肿量(OR=1.812、1.782、1.611,95%CI=1.218~5.539、1.201~5.210、1.182~4.281)、及血清tau蛋白浓度(OR=1.202、1.197、1.128;95%CI=1.079~4.721、1.071~4.209、1.059~3.581)(P均<0.01)。结论脑出血患者血清tau蛋白浓度显著升高,且与脑出血严重程度明显相关,可预测脑出血短长期的临床预后。
引用
收藏
页码:107 / 112
页数:6
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