血清tau蛋白对颅内出血患者结局的预测价值

被引：6

作者：

程振宇

陈亦华

林小峰

机构：

[1] 浙江省金华市人民医院神经外科

来源：

中华危重症医学杂志(电子版) | 2014年 / 7卷 / 02期

关键词：

tau蛋白; 脑出血; 预后;

D O I：

暂无

中图分类号：

R743.34 [脑出血];

学科分类号：

摘要：

目的研究血清tau蛋白浓度对颅内出血(ICH)预后的预测价值。方法选取2010年12月至2012年12月金华市人民医院神经外科收治的98例急性基底节出血患者(ICH组)和98例同期年龄匹配的健康体检者(对照组)作前瞻性研究。ICH组患者在脑出血后1.0～13.8 h而对照组在入院时即测定血清tau蛋白浓度,分析ICH患者预后的独立危险因素。结果血清tau蛋白浓度与血肿量和美国国立卫生院神经功能缺损(NIHSS)评分呈显著正相关(r=0.620、0.594,P均<0.01),且ICH组患者血清tau蛋白浓度较对照组显著升高(t=19.278,P<0.01)。多变量二分类Logistic回归分析显示,ICH组患者住院期间死亡、三个月死亡及三个月预后不良(改良Rankin评分>2分)的独立危险因素均为NIHSS评分(OR=1.411、1.397、1.286,95%CI=1.110～4.521、1.103～4.224、1.097～3.923)、血肿量(OR=1.812、1.782、1.611,95%CI=1.218～5.539、1.201～5.210、1.182～4.281)、及血清tau蛋白浓度(OR=1.202、1.197、1.128;95%CI=1.079～4.721、1.071～4.209、1.059～3.581)(P均<0.01)。结论脑出血患者血清tau蛋白浓度显著升高,且与脑出血严重程度明显相关,可预测脑出血短长期的临床预后。

引用

页码：107 / 112

页数：6

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