缺血后处理对缺血/再灌注胃黏膜自由基损伤的影响

被引：3

作者：

丁雷 ^{[1
]}

张建福 ^{[2
,3
]}

杜东书 ^{[3
]}

机构：

[1] 徐州医学院病理生理学教研室

[2] 徐州医学院生理学教研室

[3] 徐州医学院神经生物学研究中心

来源：

徐州医学院学报 | 2009年 / 05期

关键词：

胃缺血/再灌注; 缺血后处理; 自由基;

D O I：

暂无

中图分类号：

R363 [病理生理学];

学科分类号：

100104 ;

摘要：

目的研究缺血后处理(ischemic post-conditioning,I-postC)对大鼠胃缺血/再灌注(gastric ischemia/reperfusion,GI/R)损伤的影响。方法健康SD大鼠18只,随机分为3组,即对照组、缺血/再灌注组、缺血后处理组,分别检测大鼠胃黏膜损伤指数(GMDI)及胃黏膜组织抑制羟自由基能力、黄嘌呤氧化酶(XOD)、丙二醛(MDA)、超氧化物歧化酶(SOD)含量。结果缺血/再灌注可造成胃黏膜明显损伤;缺血后处理明显减轻GI/R损伤,并使胃黏膜组织抑制羟自由基能力、SOD含量增加,XOD、MDA明显降低。结论缺血后处理减轻大鼠胃缺血/再灌注损伤,其保护机制与减轻缺血/再灌注胃黏膜自由基损伤有关。

引用

页码：298 / 300

页数：3

共 8 条

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