小鼠动物实验方法系列专题(五) 应用高架十字迷宫分析小鼠焦虑行为

被引：65

作者：

王维刚 ^{[1
,2
]}

吴文婷 ^{[3
]}

周嘉斌 ^{[3
]}

严惠敏 ^{[3
]}

机构：

[1] 同济大学化学系

[2] 同济大学生命科学与技术学院

[3] 上海南方模式生物研究中心

来源：

中国细胞生物学学报 | 2011年 / 33卷 / 05期

关键词：

高架十字迷宫; 焦虑; 行为学; 小鼠;

D O I：

暂无

中图分类号：

R-331 [实验方法与设备];

学科分类号：

100234 [放射肿瘤学];

摘要：

高架十字迷宫(the elevated plus maze,EPM)是研究小鼠焦虑行为的重要实验,本文介绍了EPM的原理和实验步骤。将小鼠置于开臂闭臂接合处,面向开臂,通过录像记录分析小鼠在EPM的表现。结果发现,两种小鼠均可成功完成实验,C57小鼠在EPM内较不活跃,闭臂滞留时间占总时间百分比显著高于129Sv小鼠。应用EPM可以简单直观地分析小鼠焦虑行为。

引用

页码：466 / 472

页数：7

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