反复热性惊厥对大鼠学习记忆的影响及其机制

被引：26

作者：

常杏芝

秦炯

游石琼

李朝阳

吴希如

机构：

[1] 北京大学第一医院儿科,北京大学第一医院儿科,山西省儿童医院,北京大学第一医院儿科,北京大学第一医院儿科,,,

来源：

实用儿科临床杂志 | 2003年 / 03期

关键词：

热性惊厥; 学习记忆; 苔藓纤维发芽;

D O I：

暂无

中图分类号：

R720.597 [儿科急症及处理];

学科分类号：

100202 ;

摘要：

目的　观察热性惊厥对学习记忆的影响及其与海马苔藓纤维发芽的关系。方法　采用热水浴诱导惊厥模型 ,诱导生后 2 2dSD大鼠发生 15次热性惊厥。采用Morris水迷宫方法检测大鼠惊厥后近期和远期 (3个月后 )空间学习记忆能力 ;采用Timm染色观察海马颗粒细胞苔藓纤维发芽现象。结果　热性惊厥组大鼠在惊厥后早期和 3个月后的寻找平台潜伏期均较对照组明显延长。Timm染色显示惊厥 15次大鼠海马区有明显的苔藓纤维发芽现象 ,持续至 3个月后。结论　反复热性惊厥可造成学习记忆损伤 ,海马苔藓纤维发芽可能是其发生的潜在基础

引用

页码：169 / 171

页数：3

共 10 条

[1]

Consequences of neonatal seizures in the rat: morphological and behavioral effects. Holmes GL,Gairsa JL,Chevassus-Au-Louis N,et al. Annals of Neurology . 1998

[2]

Do seizures cause brain damage. Holmes GL. Epilepsia . 1991

[3]

Infrapyramidal mossy fibers and two-way avoidance learning : developmental modification of hippocampal circuitry and adult behavior of rats and mice. Lipp HP,Schwegler H,Heimrich B,et al. The Journal of Neuroscience . 1988

[4]

Prolonged febrile seizures in the immature rat model enhance hippocampal excitability long term. Dube C,Chen K,Eghbal-Ahmadi M,et al. Annals of Neurology . 2000

[5]

Postnatal modification of hippocampal circuitry alters avoidance learning in adult rats. Lipp HP,Schwegler H,Driscoll P. Science . 1984

[6]

Developments of a water-maze procedure for studying spatial learning in the rat. Morris R. Journal of Neuroscience Methods . 1984

[7]

Neuropathology of hyperthermic seizures in the rat. Jiang W,Duong TM,De Lanerolle NC. Epilepsia . 1999

[8]

Electrophysiology of dentate granule cells after kainate-induced synaptic reorganization of the mossy fiber. Cronin J,Obenaus A,Houser CR,et al. Brain Research . 1992

[9]

Chronic seizures and collateral sprouting of dentate mossy fibers after kainic acid treatment in rats. Cronin J,Dudek FE. Brain Research . 1988

[10]

A clinical approach to the child with seizures and epilepsy. Freeman JM. Epilepsia . 1987

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