蛋白激酶C激活与糖尿病肾病

被引:6
作者
张莹
机构
[1] 大连医科大学附属二院内分泌科辽宁大连
关键词
蛋白激酶C; 糖尿病肾病; 多元醇通路; 氧化应激; 非酶糖化产物;
D O I
暂无
中图分类号
R587.202 [];
学科分类号
1002 ; 100201 ;
摘要
近年来 ,二脂酰甘油 蛋白激酶C(PKC)通路的活化在糖尿病肾病 (DN)中的作用日益引起人们的关注。研究显示 ,高糖时 ,多元醇通路的激活、氧化应激可促进PKC的活化 ;糖化产物的形成可通过PKC介导促进DN的发展 ;而PKC的活化又与血管紧张素Ⅱ、内皮素 1的生成及其作用相互影响 ,所以PKC的活化已成为DN多种发病机制联系的纽带。
引用
收藏
页码:386 / 388
页数:3
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