解淀粉芽孢杆菌SC06对环磷酰胺诱导的免疫抑制小鼠免疫功能的影响

被引：5

作者：

杜威

黄琴

付爱坤

余东游

李卫芬

机构：

[1] 浙江大学动物科学学院饲料科学研究所,农业部动物营养与饲料重点开放实验室

来源：

中国畜牧杂志 | 2015年 / 51卷 / 01期

关键词：

解淀粉芽胞杆菌; 免疫抑制; 体液免疫; 细胞免疫; 小鼠;

D O I：

暂无

中图分类号：

S865.13 [];

学科分类号：

摘要：

通过连续3 d腹腔注射免疫抑制剂环磷酰胺(CTX)建立BALB/c小鼠免疫抑制模型,研究解淀粉芽孢杆菌SC06对其体液和细胞免疫功能的影响。结果表明:相比对照组,CTX会显著降低小鼠血清抗体滴度、溶血空斑数、吞噬细胞呼吸爆发活性及单核巨噬系统廓清指数K(P<0.01),降低其体液和细胞免疫功能;同时显著提高小鼠脾脏CD3+、CD4+细胞数和CD4/CD8(P<0.01),降低Th1和Tc1细胞数(P<0.01),抑制细胞免疫反应,但对NK细胞杀伤活性和淋巴细胞增殖功能无影响(P>0.05);解淀粉芽孢杆菌SC06能显著提高CTX降低的吞噬细胞呼吸爆发活性及单核巨噬系统廓清指数K(P<0.01),其他体液和细胞免疫指标相比CTX组无显著差异(P>0.05)。以上结果说明,解淀粉芽孢杆菌SC06对免疫抑制小鼠的体液及细胞免疫功能起到部分恢复和增强功能。

引用

页码：60 / 64

页数：5

共 8 条

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