硝酸铋预处理对顺铂肾毒性的防护作用

被引:5
作者
严忠群
王琍文
杨彤
张素英
周琴
机构
[1] 大连医学院药理教研室,大连医学院药理教研室,大连医学院药理教研室,大连医学院药理教研室,大连医学院药理教研室大连,大连,大连,大连山西省汾阳高级护校,大连
关键词
硝酸铋; 顺铂; 肾毒性; 金属硫蛋白; 防护作用;
D O I
暂无
中图分类号
学科分类号
摘要
大鼠预先sc硝酸铋(30μmol·kg-1·d-1)连续3d,可显著降低肾毒性剂量顺铂(5mg·kg-1)引起的尿蛋白含量,尿NAG活性和BUN水平的升高;并可有效地防护顺铂造成的肾脏髓层外带近端小管坏死,铋对肾脏MT合成有诱导作用,这可能与其防护顺铂的急性肾毒性有关。
引用
收藏
页码:281 / 284
页数:4
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