缺血修饰白蛋白在急性胸痛患者中早期诊断价值研究

被引:5
作者
邵江 [1 ]
牟华明 [1 ]
庞小华 [1 ]
李俊 [1 ]
涂雪梅 [1 ]
罗海峰 [2 ]
机构
[1] 重庆三峡中心医院心血管内科
[2] 重庆三峡中心医院检验科
关键词
缺血修饰白蛋白(IMA); 急性冠脉综合征(ACS); 高敏肌钙蛋白T(hs-TnT); 急性胸痛;
D O I
10.13201/j.issn.1009-5918.2014.03.006
中图分类号
R541.4 [冠状动脉(粥样)硬化性心脏病(冠心病)];
学科分类号
100201 [内科学];
摘要
目的:探讨血清缺血修饰白蛋白(Ischemia modified albumin,IMA)在急性胸痛患者中的早期诊断价值。方法:随机选取以急性胸痛症状入院的患者113例。根据高敏肌钙蛋白(hs-TnT)检测结果,最终确诊为ACS(Acute coronary syndrome)胸痛组59例,非ACS胸痛组54例。另选择同期来我院体检的健康者60例作为对照组。分别于入院后即刻、4~8h、24h采血检测患者血清IMA及hs-TnT。组间比较采用t检验,并通过ROC曲线取得IMA诊断ACS最佳cut-off值。结果:ACS胸痛组与非ACS胸痛组、对照组相比,IMA水平明显增高,差异具有统计学意义(P<0.05);ACS胸痛组3次IMA测量值间均有显著统计学差异(P<0.05),且IMA在入院后4~8h达到最高;ROC曲线下面积为0.872,选择81.3Uoml-1为诊断临界点时,特异度为88.9%,灵敏度为74.6%。结论:血清IMA可能是急性胸痛患者早期诊断ACS的重要指标。
引用
收藏
页码:138 / 140+143 +143
页数:4
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