乳腺癌TGF-β信号通路相关转录因子研究进展

被引：6

作者：

周雨晴

金敏

祖旭宇

机构：

[1] 南华大学附属第一医院

来源：

中华肿瘤防治杂志 | 2016年 / 23卷 / 15期

基金：

湖南省自然科学基金;

关键词：

乳腺癌; TGF-β信号通路; 转录因子; 侵袭转移; 综述文献;

D O I：

10.16073/j.cnki.cjcpt.2016.15.014

中图分类号：

R737.9 [乳腺肿瘤];

学科分类号：

摘要：

目的总结与转化生长因子β(transforming growth factor-β,TGF-β)信号通路相关的转录因子在乳腺癌发生发展过程中的作用,分析它们与TGF-β信号通路之间的网络调控机制。方法应用PubMed及CNKI期刊全文数据库检索系统,以"乳腺癌、转录因子和TGF-β"等为关键词,检索2011-01-01-2015-12-31的相关文献。纳入标准:(1)乳腺癌侵袭转移;(2)转录因子与TGF-β信号通路存在联系。剔除标准:(1)未阐明转录因子与TGF-β信号通路作用的具体机制;(2)实验设计不严谨。符合纳入标准的英文文献146篇,中文文献35篇,根据剔除标准剔除英文文献50篇,中文文献34篇,最后纳入分析文献88篇。结果 TGF-β信号通路是一条极为重要的细胞内信号转导途径,能调控细胞增殖、分化、迁移、粘附及凋亡等生理活动。在乳腺癌中,TGF-β信号通路起着双重作用,即在肿瘤发生的早期阶段,TGF-β信号通路起着一种预防性或肿瘤抑制的作用,但随着肿瘤的发展,TGF-β能够通过影响肿瘤微环境、增强侵袭性及抑制免疫细胞功能来促进肿瘤细胞的转移。多个转录因子c-Myc、p53、C/EBPβ、14-3-3ζ、Blimp-1、Oct-4和Nanog、Foxq1、TBX3、FOXM1、GATA3、HOXB9、Six1、Pokemon、Snail、Slug和SOX4已证实与TGF-β信号通路发生相互作用,共同参与调控乳腺癌发生发展过程。结论乳腺癌发生过程中转录因子与TGF-β信号通路形成复杂的调控网络,对乳腺癌的进程起着双向调节作用。

引用

页码：1041 / 1048

页数：8

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