细胞因子与类风湿关节炎的研究进展

被引:41
作者
张军芳
蒋飞霞
张宜
夏永祥
机构
[1] 南京医科大学附属南京第一医院医学检验科
关键词
类风湿关节炎; 白细胞介素; 肿瘤坏死因子; 基质金属蛋白酶;
D O I
10.13241/j.cnki.pmb.2012.04.036
中图分类号
R593.22 [类风湿性关节炎];
学科分类号
100201 [内科学];
摘要
类风湿关节炎(RA)是一种慢性、多系统的以关节的炎症损害为主要特点的自身免疫性疾病。其发病过程与多种细胞因子有关,包括TNF-α、IL-1、MMPS、IL-6、IL-17、IL-18等,这些细胞因子在RA的发病进程中起了很重要的作用,可作为治疗RA的新靶点。
引用
收藏
页码:735 / 738
页数:4
相关论文
共 15 条
[1]
Population Pharmacokinetic Analysis of Tocilizumab in Patients With Rheumatoid Arthritis [J].
Frey, Nicolas ;
Grange, Susan ;
Woodworth, Thasia .
JOURNAL OF CLINICAL PHARMACOLOGY, 2010, 50 (07) :754-766
[2]
The weight of interleukin-6 in B cell-related autoimmune disorders [J].
Youinou, Pierre ;
Jamin, Christophe .
JOURNAL OF AUTOIMMUNITY, 2009, 32 (3-4) :206-210
[3]
Interleukin-17 gene expression in patients with rheumatoid arthritis [J].
Kohno, Mika ;
Tsutsumi, Akito ;
Matsui, Hiroto ;
Sugihara, Makoto ;
Suzuki, Takeshi ;
Mamura, Mizuko ;
Goto, Daisuke ;
Matsumoto, Isao ;
Ito, Satoshi ;
Suguro, Toru ;
Sumida, Takayuki .
MODERN RHEUMATOLOGY, 2008, 18 (01) :15-22
[4]
Targeting the development and effector functions of TH17 cells [J].
Ghilardi, Nico ;
Ouyang, Wenjun .
SEMINARS IN IMMUNOLOGY, 2007, 19 (06) :383-393
[5]
Variation in the matrix metalloproteinase-3,-7,-12 and-13 genes is associated with functional status in rheumatoid arthritis [J].
Ye, S. ;
Patodi, N. ;
Walker-Bone, K. ;
Reading, I. ;
Cooper, C. ;
Dennison, E. .
INTERNATIONAL JOURNAL OF IMMUNOGENETICS, 2007, 34 (02) :81-85
[6]
Synovial proinflammatory cytokines and their correlation with matrix metalloproteinase-3 expression in Behçet’s disease. Does interleukin-1β play a major role in Behçet’s synovitis? [J].
Salih Pay ;
Hakan Erdem ;
Aysel Pekel ;
Ismail Simsek ;
Ugur Musabak ;
Ali Sengul ;
Ayhan Dinc .
Rheumatology International, 2006, 26 :608-613
[7]
Clinical significance of IL-18, IL-15, IL-12 and TNF-α measurement in rheumatoid arthritis [J].
Petrovic-Rackov, Ljiljana ;
Pejnovic, Nada .
CLINICAL RHEUMATOLOGY, 2006, 25 (04) :448-452
[8]
Der Interleukin-1-RezeptorantagonistAnakinra (Kineret®) in der Behandlungmit rheumatoider Arthritis.[J].Andrea Rubbert-Roth;Andreas Perniok.Zeitschrift für Rheumatologie.2003, 4
[9]
IL-6/IL-6受体与类风湿关节炎关联性研究新进展 [J].
苗平 ;
陆梅生 ;
张冬青 .
免疫学杂志, 2011, (04) :355-360
[10]
血小板、TNF-α及IL-1β与活动期类风湿关节炎的相关性研究 [J].
王志中 ;
王勇 ;
牟方祥 ;
方勇飞 ;
陈军 ;
罗彦 ;
石颖 ;
成娴 ;
吴红 ;
蒋毅 .
第三军医大学学报, 2011, 33 (05) :469-472