中药质谱分析方法及应用研究

被引:17
作者
李雪 [1 ,2 ,3 ,4 ]
王倩倩 [1 ,2 ,3 ,4 ]
徐晨 [1 ,2 ,3 ,4 ]
宋凤瑞 [1 ,2 ,3 ]
刘志强 [1 ,2 ,3 ]
机构
[1] 吉林省中药化学与质谱重点实验室
[2] 国家质谱中心(长春)
[3] 中国科学院长春应用化学研究所
[4] 中国科学院大学
关键词
中药; 成分分析; 活性筛选; 生物靶分子; 代谢组学;
D O I
暂无
中图分类号
O657.63 [质谱分析]; R284.1 [化学分析与鉴定];
学科分类号
070302 [分析化学]; 100804 [中药化学];
摘要
分别从中药成分分析、活性筛选和代谢组学三方面对质谱技术在中药研究中的应用进展进行了全面综述.在中药成分分析方面,重点介绍了寡糖异构体的分析方法,以及质谱指纹图谱技术在中药成分分析及质量控制中的应用;在活性筛选方面,分别介绍了超滤-质谱、细胞膜色谱-质谱、微透析-质谱、亲和色谱-质谱、强度衰减质谱、修饰琼脂糖珠-质谱和直接分析质谱等技术及其应用;在代谢组学研究方面,对中药治疗肝损伤、肾虚、心肌梗死和糖尿病等疾病方面的研究进展进行了阐述.上述内容充分反映了质谱技术在中药创新性研究中的重要性.
引用
收藏
页码:701 / 709
页数:9
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