影响急性脑梗死静脉rt-PA溶栓早期疗效的相关因素分析

被引：13

作者：

张小倩

李瞿

何志义

机构：

[1] 中国医科大学附属第一医院神经内科

来源：

实用药物与临床 | 2015年 / 18卷 / 11期

关键词：

急性脑梗死; rt-PA; 静脉溶栓; 相关因素;

D O I：

10.14053/j.cnki.ppcr.201511017

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

摘要：

目的探讨影响重组组织型纤溶酶原激活物(rt-PA)治疗急性脑梗死早期疗效的相关因素,为临床治疗提供理论依据。方法收集2013年1月至2014年9月入住我院神经内科的82例经静脉溶栓的急性脑梗死患者的相关临床资料,根据NIHSS评分,将患者分为神经功能明显改善组(NIHSS评分降低≥4分,25例)和神经功能无改善组(NIHSS评分降低<4分或者增加,57例),并应用t检验、χ2检验和Logistic回归分析方法明确影响溶栓早期疗效的相关因素。结果本研究82例患者平均(63.29±9.82)岁,溶栓前NIHSS平均分为(12.46±7.51)分,发病到用药时间平均(170.48±62.41)min。单因素分析中,神经功能明显改善组和无改善两组高血压例数(9例vs.36例,P=0.031)、糖尿病例数(1例vs.18例,P=0.022)、发病到溶栓时间[(145.20±7.81)min vs.(183.30±8.23)min,P=0.001]之间差异有统计学意义,而多因素Logistic分析证实只有糖尿病(P=0.044,OR=8.736)和发病到溶栓时间(P=0.038,OR=1.011)在两组间差异有统计学意义,是影响疗效的独立相关因素。结论脑梗死合并糖尿病、发病时间长的患者静脉溶栓效果不佳。

引用

页码：1335 / 1338

页数：4

共 13 条

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