颞下颌关节骨关节病基因治疗的研究进展

被引：3

作者：

杨彬

张志光

机构：

[1] 中山大学光华口腔医学院·附属口腔医院·口腔医学研究所

来源：

国际口腔医学杂志 | 2010年 / 37卷 / 05期

关键词：

颞下颌关节; 骨关节病; 基因治疗;

D O I：

暂无

中图分类号：

R782.6 [颞下颌关节疾病];

学科分类号：

100213 [耳鼻咽喉科学];

摘要：

骨关节病是常见的关节退行性疾病,以软骨损伤为特征,常规治疗效果不理想,基因治疗作为新的技术近年来已经开始用于关节病的治疗。颞下颌关节是活动最频繁的滑膜关节之一,出生后即开始发生不断地改建,以适应不同年龄阶段咀嚼功能的需要,其结构与功能对于维持口颌系统的平衡起着重要作用。颞下颌关节虽然体积小,但却承担了相对较大的咀嚼力,因此较其他的大关节更容易发生骨关节病。本文对颞下颌关节骨关节病基因治疗的靶细胞、目的基因和载体等的研究进展作一综述。

引用

页码：608 / 612

页数：5

共 12 条

[1]

Concepts in gene therapy for cartilage repair.[J]..Injury.2008, 1

[2]

IGF-1 gene therapy to protect articular cartilage in a rat model of joint damage [J].

Izal, Inigo ;

Acosta, Carlos Alberto ;

Ripalda, Purificacion ;

Zaratiegui, Mikel ;

Ruiz, Juan ;

Forriol, Francisco .

ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY, 2008, 128 (02) :239-247

[3]

Adenovirus-mediated expression of growth and differentiation factor-5 promotes chondrogenesis of adipose stem cells [J].

Feng, Gang ;

Wan, Yuqing ;

Balian, Gary ;

Laurencin, Cato T. ;

Li, Xudong .

GROWTH FACTORS, 2008, 26 (03) :132-142

[4]

Direct chitosan-mediated gene delivery to the rabbit knee joints in vitro and in vivo [J].

Zhang, XL ;

Yu, CL ;

XuShi ;

Zhang, C ;

Tang, TT ;

Dai, KR .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 341 (01) :202-208

[5]

Regional gene therapy for full-thickness articular cartilage lesions using naked DNA with a collagen matrix [J].

Di Cesare, PE ;

Frenkel, SR ;

Carlson, CS ;

Fang, C ;

Liu, CJ .

JOURNAL OF ORTHOPAEDIC RESEARCH, 2006, 24 (05) :1118-1127

[6]

Cartilage repair using bone morphogenetic protein 4 and muscle-derived stem cells [J].

Kuroda, R ;

Usas, A ;

Kubo, S ;

Corsi, K ;

Peng, HR ;

Rose, T ;

Cummins, J ;

Fu, FH ;

Huard, J .

ARTHRITIS AND RHEUMATISM, 2006, 54 (02) :433-442

[7]

Acceleration of cartilage repair by genetically modified chondrocytes over expressing bone morphogenetic protein-7 [J].

Hidaka, C ;

Goodrich, LR ;

Chen, CT ;

Warren, RF ;

Crystal, RG ;

Nixon, AJ .

JOURNAL OF ORTHOPAEDIC RESEARCH, 2003, 21 (04) :573-583

[8]

High-efficiency non-viral transfection of primary chondrocytes and perichondrial cells for ex-vivo gene therapy to repair articular cartilage defects [J].

Goomer, RS ;

Deftos, LJ ;

Terkeltaub, R ;

Maris, T ;

Lee, MC ;

Harwood, FL ;

Amiel, D .

OSTEOARTHRITIS AND CARTILAGE, 2001, 9 (03) :248-256

[9]

IGF-I and mechanical environment interact to modulate engineered cartilage development [J].

Gooch, KJ ;

Blunk, T ;

Courter, DL ;

Sieminski, AL ;

Bursac, PM ;

Vunjak-Novakovic, G ;

Freed, LE .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 286 (05) :909-915

[10]

Cationic polymer-mediated genetic transduction into cultured human chondrosarcoma-derived HCS-2/8 cells.[J].Suzuyo Ohashi;Toshikazu Kubo;Takumi Ikeda;Yuji Arai;Kenji Takahashi;Yasusuke Hirasawa;Masaharu Takigawa;Etsuko Satoh;Jiro Imanishi;Osam Mazda.Journal of Orthopaedic Science.2001, 1

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