罗格列酮与阿尔茨海默病

被引：16

作者：

张旭 ^{[1
,2
]}

王蓉 ^{[1
,2
]}

机构：

[1] 首都医科大学宣武医院中心实验室北京市老年病医疗研究中心

[2] 教育部神经变性病重点实验室

来源：

首都医科大学学报 | 2011年 / 32卷 / 01期

基金：

北京市自然科学基金;

关键词：

过氧化物酶体增殖物激活受体γ; 罗格列酮; 阿尔茨海默病; β-淀粉样肽; 炎性反应; 载脂蛋白E;

D O I：

暂无

中图分类号：

R749.16 [];

学科分类号：

摘要：

随着人类步入老龄化社会,阿尔茨海默病(Alzheimer's disease,AD)的发病率不断增加,但其发病机制仍不明确,缺乏有效的治疗手段。近年来研究发现AD的患病风险与2型糖尿病具有一定相关性。有证据表明,治疗2型糖尿病的噻唑烷二酮类氧化物酶体增殖物激活受体γ(peroxisome proliferator-activated receptor gamma,PPARγ)激动剂罗格列酮可以改善AD患者和AD动物模型中与此疾病相关的病理变化和学习记忆功能。本文对以上内容和罗格列酮对AD的作用机制进行综述。

引用

页码：95 / 99

页数：5

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