Wee1蛋白激酶的研究进展

被引：7

作者：

袁会军 ^{[1
]}

刘斌 ^{[2
]}

杨艳丽 ^{[2
]}

范钰 ^{[1
]}

李晶晶 ^{[1
]}

机构：

[1] 甘肃中医药大学基础医学院

[2] 解放军兰州总医院病理科

来源：

中国癌症防治杂志 | 2018年 / 10卷 / 01期

关键词：

Wee1蛋白激酶; DNA损伤修复; 细胞周期; Wee1抑制剂; AZD-1775;

D O I：

暂无

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

100214 [肿瘤学];

摘要：

Wee1是丝氨酸/苏氨酸蛋白激酶家族的一员,在多种肿瘤中过表达,抑制Wee1蛋白激酶活性可引起细胞死亡或永久性细胞生长停滞。研究证明Wee1可作为治疗肿瘤的靶点,其特异性小分子抑制剂AZD-1775(也称为MK1775)已进入临床Ⅱ期试验。本文就Wee1蛋白激酶的结构及其在细胞周期和恶性肿瘤中的作用作一综述。

引用

页码：61 / 64

页数：4

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