再生障碍性贫血骨髓血管生成的研究

被引：4

作者：

季健玲 ^{[1
]}

徐美玉 ^{[1
]}

黄锋 ^{[1
]}

刘红 ^{[2
]}

机构：

[1] 南通大学附属医院儿科

[2] 南通大学附属医院血液科

来源：

中国实验血液学杂志 | 2006年 / 01期

关键词：

再生障碍性贫血; 血管生成; CD34细胞; 骨髓;

D O I：

暂无

中图分类号：

R556 [贫血病];

学科分类号：

摘要：

本研究目的为探讨再生障碍性贫血骨髓血管生成的状况。采用免疫组织化学SP法检测32例再生障碍性贫血患者和16例正常人骨髓活检组织中血管内皮细胞标记CD34的表达,用盲法计数骨髓微血管密度(MVD)并对骨髓血管生成进行简单分级。结果表明,再生障碍性贫血患者骨髓MVD显著低于正常人(P<0.01),其中重型再生障碍性贫血和非重型再生障碍性贫血的MVD都显著低于正常人(P<0.01),而重型再生障碍性贫血MVD值低于非重型再生障碍性贫血(P<0.05)。再生障碍性贫血患者MVD与血管简单分级之间存在正相关性(r=0.64,P<0.01)。结论:再生障碍性贫血患者骨髓血管生成缺陷可能导致或加重骨髓造血障碍。

引用

页码：79 / 82

页数：4

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