瘦素生理作用研究现状

被引:12
作者
曲世平
程洁
机构
[1] 青岛市内分泌糖尿病医院!山东青岛
关键词
瘦素; 生殖发育; 骨代谢; 血压;
D O I
暂无
中图分类号
R589 [代谢病];
学科分类号
1002 ; 100201 ;
摘要
瘦素受体广泛分布于中枢和外周组织 ,瘦素与其受体结合后 ,发挥一系列生理作用。除影响体脂和能量代谢过程外 ,尚可促进生殖系统成熟 ,始动青春发育 ;影响骨骼发育和重建 ;调节血管张力和血小板的粘附性 ,与肥胖相关性高血压和血栓形成的关系密切。在机体应激和免疫防御系统中 ,瘦素也显示了一定的作用。
引用
收藏
页码:192 / 195
页数:4
相关论文
共 10 条
[1]  
High plasma leptin concentrations in hypertensive men but not in women. Sheu W H,Lee,W J,Chen Y T,et al. Journal of Hypertension . 1999
[2]  
Leptin and the perioperative neuroendocrinological stress response. Kain Z N,Zimolo Z,Heninger G. The Journal of Clinical Endocrinology . 1999
[3]  
Expression of leptin receptor in normal human adrenals differential regulation of adrenocortical and adrenomedullary function by leptin. Gasow A,Haidan A,Hilbers U,et al. The Journal of Clinical Endocrinology . 1998
[4]  
Diabetes[P]. 英国专利:GB201117172D0,2011-11-16
[5]  
Increased leptin concentrations in preterm infants of pre-eclampic mothers. Hytinantti T,Koistinen H A,Koivisto V S,et al. Archives of Disease in Childhood . 2000
[6]  
The hypothalamus and the regulation of energy homeostasis: lifting the lid on a black box. Williams G,Harrold J A,Cutler D J,et al. Proceedings of the Nutrition Society . 2000
[7]  
Involvement of nitric oxide in endothelium-dependent arterial relaxation by leptin. Kimura K,Tsuda K,Baba A,et al. Biochemical and Biophysical Research Communications . 2000
[8]  
Diabetes[P]. 英国专利:GB201117172D0,2011-11-16
[9]  
Distribution of leptin receptor mRNA isforms in rat brain. Elmquist J K,Bjorbaek C,Ahima R S,et al. Journal of Comparative Neurology . 1998
[10]  
Plasma leptin in female athletes relationship with body fat,reproductive,nutritional,and endocrine factors. Thong FS,MC lean C,Graham T E,et al. Journal of Applied Physiology . 2000