急性缺血性脑卒中溶栓治疗研究进展

被引:27
作者
谢晓川
饶莉
机构
[1] 四川大学华西医院心脏内科
关键词
急性缺血性脑卒中; 溶栓治疗; 组织型纤维蛋白溶解酶原激活物; 新型溶栓药物;
D O I
暂无
中图分类号
R743.3 [急性脑血管疾病(中风)];
学科分类号
摘要
急性缺血性脑卒中是具有极高病死率和致残率的常见脑血管疾病,其治疗目标在于迅速恢复缺血脑组织血流灌注,以防止脑组织坏死和功能丧失,药物溶栓是其重要治疗手段。近年来,药物溶栓治疗发展迅速,新型溶栓药物及相关研究不断涌现。大量研究结果表明,与传统溶栓药物如组织型纤维蛋白溶解酶原激活物(t-PA)相比,新型溶栓药物如替奈普酶、去氨普酶和安克洛酶与纤维蛋白亲和力更强且半衰期更长,能提供更为稳定有效的溶栓效果且安全性更佳。该文重点综述评估使用t-PA及新型溶栓药物治疗急性缺血性脑卒中有效性和安全性的相关研究结果,讨论溶栓药物的选择、影响溶栓药物临床疗效的相关因素及超声辅助溶栓等药物溶栓治疗的辅助手段。
引用
收藏
页码:1610 / 1613
页数:4
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