CD40-CD40L与急性冠脉综合征的研究进展

被引:19
作者
周启林
田国平
机构
[1] 南华大学附属第二医院心内科
关键词
CD40; CD40L; 冠脉综合征,急性; 抗CD40L抗体;
D O I
10.13191/j.chj.2006.02.125.zhouql.038
中图分类号
R541.4 [冠状动脉(粥样)硬化性心脏病(冠心病)];
学科分类号
摘要
本文介绍了CD40与CD40L的生物学特性,包括其分布、来源、信号转导机制。综述了CD40-CD40L与慢性炎症、免疫调节、血栓形成、斑块不稳定的相关性,提示抗CD40L治疗是未来防治急性冠脉综合征的一个方向。
引用
收藏
页码:239 / 241
页数:3
相关论文
共 11 条
[1]  
CD154(CD40 ligand). Schonbeck U,Mach F,L ibby P. Int JBiochem cell Bio,l . 2000
[2]  
l CD40 ligand inh ib its endo-thelial cellm igration by increasing production of endothelial reactiveoxygen species. U ib ich C,D ernbach E,A icher A,et a. Circulation . 2002
[3]  
3-hydroxy-3-m ethylgl-utaryl coenzym e A reductase-independent inh ib ition of CD40 expres-sion by atorvastatin in human endothelial cells. W agnerAH,GebauerM,Gu ldenzoph B,et al. ArteriosclerThrom b Vasc Biol . 2002
[4]  
Solub le CD40 ligand inacute coronary syndrom es. Heeschen C,D imm eler S,Hamm CW,et al. The New England Journal of Medicine . 2003
[5]  
l Upregu lation of CD40 andCD40 ligand(CD154)in patients w ith moderate hypercholesterol-em ia. Garlichs CD,John S,Schm eisser A,et a. Circulation . 2001
[6]  
Inh ib ition of CD40 sig-naling lim its evolution of estab lished atherosclerosis in m ice. Schonbeck U,Sukhova GK,Sh im izu K,et al. Proceedings of the National Academy of Sciences of the United States of America . 2004
[7]  
G lucocorticoids upregu late CD40ligand expression and CD40L-dependent immunoglobu lin isotypesw itch ing. Jabara HH,B rodeuer SR,Geha RS. J C lin Inves,t . 2001
[8]  
l Solub le CD40L and card iovas-cu lar risk in wom en. Schonbeck U,Varo N,L ibby P,et a. Circulation . 2001
[9]  
l CD40L stab ilizes arterisl throm-b i by a beta 3 integrin-dependentm echan ism. Andre P,Prasad KS,D en is CV,et a. NatM ed . 2002
[10]  
Sustained platelet activation fol-low ing intracoronary beta irrad iation. Krotz F,Sch ieleTM,Zahler S,et al. The American Journal of Cardiology . 2002