巴西蘑菇多糖诱导K562肿瘤细胞凋亡的研究

被引：5

作者：

袁丽铭

忻茜

李兴玉

机构：

[1] 上海师范大学生命与环境科学学院

来源：

食用菌学报 | 2005年 / 03期

关键词：

巴西蘑菇多糖; 诱导; K562肿瘤细胞; 细胞凋亡;

D O I：

10.16488/j.cnki.1005-9873.2005.03.007

中图分类号：

R73-3 [肿瘤学实验研究];

学科分类号：

摘要：

应用流式细胞分选仪(Flow cell sorter,FCS)和透射电子显微镜(Transmissional elec-tron microscope,TEM)等技术观察了巴西蘑菇(Agaricus blazei)多糖诱导K562肿瘤细胞凋亡的试验研究。试验发现,流式细胞仪可检测到经巴西蘑菇多糖诱导K562肿瘤96h后产生明显的亚二倍体峰;电镜下观察到K562肿瘤细胞核固缩,核内染色质浓缩、凝聚,紧靠在细胞核膜边沿,形成新月状或环状结构等典型的凋亡细胞的形态变化及凋亡小体。结果表明,巴西蘑菇多糖具有诱导K562肿瘤细胞凋亡的作用。

引用

页码：38 / 42

页数：5

共 10 条

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