S100B在慢性心力衰竭诊疗中的临床意义

被引：4

作者：

任妍

虞莹珺

李金平

苏倩

周清芬

张凤如

机构：

[1] 上海交通大学医学院附属瑞金医院老年科

来源：

国际心血管病杂志 | 2012年 / 39卷 / 06期

关键词：

慢性心力衰竭; S100B; 预后转归;

D O I：

暂无

中图分类号：

R541.6 [血液循环衰竭];

学科分类号：

100201 [内科学];

摘要：

目的:探讨慢性心力衰竭(CHF)患者血清S100B蛋白水平与心功能及CHF病因的关系。方法:将234例CHF患者按病因分为扩张型心肌病组(n=133)和缺血性心肌病组(n=101),并以117名正常人作为对照组。测定血清S100B、N-末端B型利钠肽原(NT-proBNP)和高敏C反应蛋白(hsCRP)水平。结果:CHF患者S100B水平明显升高,血清S100B水平与左室射血分数(LVEF)及NT-proBNP呈相关性。S100B蛋白水平较高的患者发生主要心血管终点事件风险较高,但在缺血性心肌病组与扩张型心肌病组中蛋白水平无明显差异。结论:S100B蛋白水平在慢性心力衰竭患者中明显升高,且与患者心功能呈负相关,是慢性心力衰竭发生发展的独立危险因素,对于慢性心力衰竭患者的预后转归有提示意义。

引用

页码：385 / 388

页数：4

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