药物性肝损伤的发病机制

被引：23

作者：

李子俊

谢子钧

机构：

[1] 广东省医学科学院广东省人民医院消化内科

来源：

中华肝脏病杂志 | 2012年 / 03期

关键词：

胆汁淤积; 免疫系统; 药物性肝损伤; 发病机制;

D O I：

暂无

中图分类号：

R575 [肝及胆疾病];

学科分类号：

100201 [内科学];

摘要：

<正>2005年,Kaplowitz曾就药物性肝损伤(drug-inducedliver injury,DILI)的机制提出了一个概念,即药物特异性损伤的"上游"事件和非特异性的"下游"事件。"上游"事件是指环境因素和遗传危险因素共同作用引起的初始肝细胞损伤;"下游"事件泛

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