孕妇巨细胞病毒感染及其母婴垂直传播

被引:22
作者
饶美兰 [1 ]
郑瑛 [1 ]
张畅斌 [2 ]
林小红 [1 ]
机构
[1] 广东省妇幼保健院产科(广州医学院附属广东省妇儿医院)
[2] 广东省妇幼保健院产前诊断科(广州医学院附属广东省妇儿医院)
关键词
孕妇; 婴儿; 巨细胞病毒; 感染;
D O I
暂无
中图分类号
R714.25 [妊娠并发症]; R512.99 [其他];
学科分类号
100211 ; 100401 ;
摘要
目的探讨孕妇巨细胞病毒(HCMV)感染及其母婴垂直传播状况。方法应用酶联免疫吸附法(ELISA)筛查11859例孕妇HCMV的特异性抗体(IgG及IgM),同时应用荧光定量PCR(FQ-PCR)技术检测其中248例具有活动性HCMV感染孕妇的羊水或胎儿脐血或产后直接抽脐血检测HCMV-DNA。结果孕妇HCMV感染率为95.3%(11306/11859),孕妇活动性HCMV感染率为3.5%(417/11859),孕中期羊水的HCMV-DNA阳性率为12.1%(12/99);孕晚期脐血或产后直接抽脐血HCMV-DNA阳性率为6.0%(9/149),羊水的HCMV-DNA阳性率与分娩期脐血及及新生儿血相比较,差异无统计学意义(P>0.05)。结论孕产妇孕前绝大多数已感染过HCMV,测定孕中期羊水的HCMV-DNA,对早期诊断先天性HCMV感染具有重要意义。
引用
收藏
页码:91 / 94
页数:4
相关论文
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