采用3.0T MRI T2和T2* mapping评价下腰痛患者腰椎间盘退变

被引:18
作者
龚静山 [1 ]
凌人男 [1 ]
周阳泱 [1 ]
朱进 [1 ]
贾桂静 [1 ]
袁家琳 [1 ]
王毅翔 [2 ]
机构
[1] 深圳市人民医院(暨南大学第二临床医学院)放射科
[2] 香港中文大学威尔士亲王医院影像诊断和介入放射科
关键词
椎间盘; 退变; 磁共振定量成像; T2 mapping; T2* mapping;
D O I
暂无
中图分类号
R681.5 [脊柱及背疾病]; R445.2 [核磁共振成像];
学科分类号
100220 [骨科学]; 100231 [临床病理学];
摘要
目的探讨下腰痛患者腰椎间盘的T2和T2*值与退变Pfirrmann分级的相关性,明确T2和T2*值是否可以作为影像学生物标记定量评价IVD退变。方法 2015年3月-2015年6月间,对66例下腰痛患者采用3.0T MRI行腰椎常规结构成像和定量成像(T2和T2*mapping)。Pfirrmann分级由两位放射诊断医生依据矢状位T2WI通过协商进行。在正中矢状位的T2 map和T2*map上由一位放射诊断医生手工绘制感兴趣区尽可能包括髓核和内层纤维环测量IVD的T2和T2*值。采用Pearson相关比较IVD的T2和T2*值与Pfirrmann分级相关性,并对相邻的Pfirrmann分级的T2和T2*值比较。结果 IVD的T2和T2*值与Pfirrmann分级呈负相关,相关系数分别为-0.612和-0.354,P值均小于0.001。PfirrmannⅠ级到Ⅲ级T2和T2*值显著降低,Ⅲ级到Ⅴ级下降变缓。除Ⅳ级与Ⅴ级IVD的T2和T2*值差别没有统计学意义外,其他相邻的Pfirrmann分级IVD的T2和T2*值差别均有统计学意义。结论 IVD的T2和T2*值具有作为影像学生物标记定量评价IVD的退变潜在可能性,有助于IVD退变的早期诊断和客观评价退变程度。晚期IVD退变T2和T2*值下降变缓,以形态学改变为主。
引用
收藏
页码:113 / 116
页数:4
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