乌司他丁和肿瘤坏死因子α抗体对大鼠肝脏缺血再灌注损伤的保护作用

被引：11

作者：

岳树强

窦科峰

李开宗

杨雁灵

徐小平

机构：

[1] 第四军医大学西京医院肝胆外科

[2] 第一军医大学珠江医院普通外科陕西西安

[3] 陕西西安

来源：

中国医师杂志 | 2004年 / 01期

关键词：

乌司他丁; 肿瘤坏死因子α; 缺血再灌注; 围手术期处理; 大鼠;

D O I：

暂无

中图分类号：

R657.3 [肝及肝管];

学科分类号：

1002 ; 100210 ;

摘要：

目的　探讨乌司他丁和肿瘤坏死因子α(TNFα)抗体对大鼠肝脏缺血再灌注损伤的保护作用。方法　雄性SD大鼠 12 0只 ,分为正常对照组、缺血再灌注组 ,TNFα抗体处理组和乌司他丁 +TNFα抗体处理组 ,观察了肝脏缺血 60min及再灌注 1、3、6及 12h后 ,检测血清丙氨酸氨基转移酶 (ALT)、丙二醛 (MDA)及肝组织病理学变化。结果　肝脏缺血再灌注后 ,肝脏瘀血明显 ,血浆ALT和MDA含量均显著增高 ;肝脏缺血再灌注用乌司他丁 +TNFα抗体处理后 ,血浆ALT和MDA含量明显降低 ,肝组织瘀血减轻。结论　乌司他丁联合TNFα抗体可以抑制大鼠肝脏缺血再灌注所致的炎症反应 ,对大鼠肝脏缺血再灌注损伤有保护作用

引用

页码：36 / 38

页数：3

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