非酒精性脂肪肝与胰岛素抵抗的研究进展

被引：36

作者：

刘超 ^{[1
]}

魏亚聪 ^{[1
]}

冯静 ^{[1
]}

李萍 ^{[2
]}

魏立民 ^{[3
,4
]}

机构：

[1] 河北医科大学研究生学院

[2] 北京世纪坛医院内分泌科

[3] 河北医科大学内科学教研室

[4] 河北省人民医院内分泌科河北省老年医学重点实验室

来源：

医学综述 | 2016年 / 22卷 / 20期

关键词：

非酒精性脂肪肝; 胰岛素抵抗; 脂肪酸; 胰岛素信号通路;

D O I：

暂无

中图分类号：

R575 [肝及胆疾病];

学科分类号：

100201 [内科学];

摘要：

非酒精性脂肪肝病(NAFLD)是以肝细胞脂肪变性和脂肪沉积为病理特征,但无过量饮酒史的临床综合征,目前NAFLD在国内外的发病率正呈明显上升趋势。胰岛素抵抗是多种代谢性疾病(如2型糖尿病、肥胖、高血压、血脂紊乱等)共同的发病基础,而很多代谢性疾病的发生与NAFLD有关。而多项研究也都证实胰岛素抵抗与NAFLD存在明显相关性,NAFLD可直接或间接地影响胰岛素信号通路。寻找NAFLD导致胰岛素抵抗的相关因素,探讨其发生、发展以及治疗的分子机制,可能将成为未来的研究方向。

引用

页码：3994 / 3998

页数：5

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