他汀类药物对阿尔茨海默病的治疗作用

被引：7

作者：

朱天瑞

李晓红

机构：

[1] 山东大学附属济南市中心医院神经内科

来源：

国际神经病学神经外科学杂志 | 2010年 / 37卷 / 01期

关键词：

阿尔茨海默病; 他汀类药物; Rho; Rho激酶;

D O I：

10.16636/j.cnki.jinn.2010.01.021

中图分类号：

R749.16 [];

学科分类号：

100203 ;

摘要：

近年来研究表明,他汀类药物有防治阿尔茨海默病(AD)的作用,但机制尚不明确。诸多研究证明他汀类药物可通过降脂作用或抑制异戊二烯化阻断Rho蛋白信号转导通路,增强α分泌酶活性,减少Aβ淀粉样蛋白的产生。本文综述了他汀类药物及Rho/ROCK途径与AD的关系,探索了他汀类药物通过Rho激酶抑制途径,影响Aβ前体蛋白(APP)代谢,发挥其对AD防治作用的机制。

引用

页码：77 / 80

页数：4

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