代谢型谷氨酸受体激动引起星形神经胶质细胞肿胀

被引：4

作者：

袁芳

王天佑

机构：

[1] 北京市神经外科研究所

[2] 北京市神经外科研究所北京

[3] 北京

来源：

中国科学C辑:生命科学 | 1996年 / 05期

关键词：

谷氨酸; trans-ACPD; 星形细胞; 肿胀; 胆罗啉; Ca2+;

D O I：

暂无

中图分类号：

R741 [神经病学];

学科分类号：

摘要：

用[3H]-3-氧-甲基-D-葡萄糖摄取的方法测定细胞水含量,观察谷氨酸受体激动剂、拮抗剂对培养的星形神经胶质细胞水含量的影响,并观察细胞内、外钙的作用.结果发现:0.5,1,10 mmol/L的谷氨酸和1mmol/L的trans-ACPD（代谢型谷氨酸受体激动剂）1h均可以引起细胞的水含量增加,1mmol/L的 AMPA（离子型谷氨酸受体激动剂）不影响细胞的水含量,1mmol/L的L-AP3（代谢型谷氨酸受体拮抗剂）可以拮抗1mmol/L谷氨酸和trans-ACPD的作用;撤除细胞外液的钙,谷氨酸不再引起细胞的水含量增加, 20 μmol/ L 的 CdCl2不能减轻谷氨酸的作用,而300μmol/L的CdCl2及30μmol/L的胆罗啉（Dantrolene）均可以减轻谷氨酸的作用,提示代谢型谷氨酸受体激动引起星形细胞肿胀,细胞内、外Ca2+在谷氨酸引起的星形细胞肿胀中起一定的作用.

引用

页码：476 / 480

页数：5

共 9 条

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