Notch信号通路在血管生成中的作用研究进展

被引：11

作者：

纵单单

陈平

陈燕

机构：

[1] 中南大学湘雅二医院呼吸内科

来源：

国际呼吸杂志 | 2012年 / 04期

关键词：

Notch信号通路; 血管生成; 内皮祖细胞; 血管内皮生长因子; 肿瘤;

D O I：

暂无

中图分类号：

R363 [病理生理学];

学科分类号：

100103 [病原生物学];

摘要：

血管生成存在于机体生长发育的各个阶段。Notch信号是细胞间相互作用的重要信使,大量的研究发现Notch信号在细胞分化及血管生成方面发挥重要的调控作用。Notch信号参与生理性血管生成可能与以下机制有关:调节尖细胞与茎细胞的分化,调节动静脉分化、内皮祖细胞、血管壁细胞、血管内皮生长因子、一氧化氮以及与其他信号通路相互作用。此外,Notch信号在肿瘤以及损伤后组织修复等病理性血管生成中亦发挥重要作用。明确Notch信号的作用机制对疾病的治疗有重要意义。

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