阿托伐他汀对肾间质纤维化大鼠间质巨噬细胞增殖的影响

被引：5

作者：

田少江

贾汝汉

丁国华

彭隽

陈玲

机构：

[1] 武汉大学人民医院肾内科

[2] 武汉大学人民医院肾内科湖北武汉

[3] 湖北武汉

来源：

中国医师杂志 | 2003年 / 04期

关键词：

间质纤维化; 巨噬细胞; 巨噬细胞集落刺激因子; 阿托伐他汀;

D O I：

暂无

中图分类号：

R692 [肾疾病];

学科分类号：

1002 ; 100210 ;

摘要：

目的　探讨阿托伐他汀对间质纤维化大鼠肾间质巨噬细胞积聚的影响及其可能的机制。方法　 2 1只大鼠随机分为假手术、单侧输尿管梗阻 (UUO)、UUO +阿托伐他汀治疗组 ,分别用免疫组化染色检测巨噬特异性抗原CD68和巨噬细胞集落刺激因子 (M -CSF)以确定肾间质巨噬细胞数和M -CSF的量 ,并常规查各组血脂。结果　单侧输尿管梗阻第 10d肾间质巨噬细胞积聚和M -CSF表达明显增加 ,阿托伐他汀治疗后二者均明显减少。模型组和治疗组巨噬细胞积聚程度与小管间质M -CSF表达呈正相关。各组血脂无显著性差异。结论　阿托伐他汀可显著减少肾间质巨噬细胞积聚程度 ,这可能与其下调小管间质M -CSF表达有关。

引用

页码：460 / 462

页数：3

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