uPA、MMP-3在退变椎间盘中的表达及意义

被引:7
作者
张宏其
罗继
陈凌强
机构
[1] 中南大学湘雅医院脊柱外科
关键词
椎间盘; 尿纤溶酶原激活物; 基质溶解素1; 免疫组织化学; 染色与标记;
D O I
暂无
中图分类号
R681.533.102 [];
学科分类号
摘要
目的探讨尿激酶型纤溶酶原激活剂(uPA)、基质金属蛋白-3(MMP-3)在人类退变椎间盘组织中的表达变化。方法对照组为取自脊柱侧凸患者的正常腰椎间盘组织;实验组为腰椎间盘突出患者的退变椎间盘组织。分别进行免疫组织化学染色,比较2组椎间盘组织中uPA及MMP-3的光密度值。结果uPA和MMP-3在突出椎间盘组织中平均光密度值较正常椎间盘组织中的平均光密度值表达明显升高;相关分析显示突出椎间盘中uPA、MMP-3呈正相关关系。结论uPA和MMP-3均可能参与了人椎间盘组织的退变过程,且MMP-3与uPA在人类退变椎间盘组织中有相同的增高趋势。
引用
收藏
页码:129 / 131
页数:3
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