充血性心力衰竭患者血管活性物质变化的临床意义

被引：21

作者：

钟萍

李志樑

唐朝枢

机构：

[1] 济南军区总医院保健一科

[2] 南方医科大学珠江医院心内科

[3] 北京大学第一医院心血管研究所 (济南

[4] )

[5] (广州

[6] (北京

来源：

中国实用内科杂志 | 2005年 / 01期

关键词：

充血性心力衰竭; 血管活性物质; 尾加压素Ⅱ; 肾上腺髓质前体N端20肽; 心房肽;

D O I：

暂无

中图分类号：

R541.6 [血液循环衰竭];

学科分类号：

1002 ; 100201 ;

摘要：

目的　研究充血性心力衰竭 (CHF)患者血浆尾加压素Ⅱ (Urotensin -Ⅱ ,UⅡ )变化与其他血管活性物质的变化 ,阐明血管活性物质的可能作用及临床意义。方法　 2 0 0 1- 0 8～ 2 0 0 2 - 0 5第一军医大学 (现南方医科大学 )珠江医院心内科对 5 2例充血性心力衰竭患者采用放射免疫方法分别检测血浆UⅡ、肾上腺髓质前体N端 2 0肽 (PAMP)以及心房肽 (ANP)血浆含量 ,同时选 2 0名体检者作为对照组。所有入选者均进行心功能检查。结果　CHF组治疗前血浆UⅡ含量明显低于对照组 [(1 4 8± 1 0 5 )与 (4 2 8± 1 2 1)pg·mL-1,P <0 0 5 ],治疗后与治疗前比较明显升高 [(2 11± 1 4 8)与 (1 4 8± 1 0 5 )pg·mL-1,P <0 0 5 ],血浆UⅡ含量降低与CHF的程度平行。治疗前血浆PAMP、ANP含量CHF组较对照组升高 [(30 6 1± 5 80 )与 (2 1 0 1± 6 5 9)pg·mL-1,P <0 0 5 ]及 [(319 88± 30 2 1)与(41 82± 6 0 9)pg·mL-1,P <0 0 5 ];治疗后血浆PAMP、ANP含量分别比治疗前下降 [(2 5 5 7± 5 0 6 )与 (30 6 1±5 80 )pg·mL-1,P <0 0 5 ]及 [(2 2 8 5 2± 2 2 0 1)与 (319 88± 30 2 1)pg·mL-1,P <0 0 5 ],但均未恢复到对照组及治疗前水平。结论　心力衰竭过程中 ,血浆UⅡ、PAMP、ANP含量均发生相应的

引用

页码：27 / 29

页数：3

共 11 条

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