沙库巴曲缬沙坦的临床应用及其潜在作用

被引：23

作者：

杨淑莲

吴晓羽

机构：

[1] 哈尔滨医科大学附属第一医院

来源：

实用心脑肺血管病杂志 | 2020年 / 28卷 / 05期

关键词：

沙库巴曲缬沙坦; 血管紧张素受体脑啡肽酶抑制剂; 心力衰竭; 高血压; 心肌梗死; 糖尿病; 心脏代谢综合征; 肾功能不全;

D O I：

暂无

中图分类号：

R972 [心血管系统药物];

学科分类号：

100117 [系统生物医学];

摘要：

沙库巴曲缬沙坦即血管紧张素受体脑啡肽酶抑制剂(ARNI),是近年来心力衰竭领域的研究热点。多项研究显示该药可明显降低心力衰竭患者的住院率和死亡率,并对多种心血管疾病有良好获益。本文简述了沙库巴曲缬沙坦在心力衰竭、高血压、急性心肌梗死、糖尿病、心脏代谢综合征和肾功能不全等疾病中的相关研究进展,进一步表明沙库巴曲缬沙坦现已不仅局限于射血分数降低的心力衰竭的临床应用,而是对多种心血管疾病甚至非心血管疾病均有潜在的有益作用。

引用

页码：82 / 86

页数：5

共 21 条

[1]

Sacubitril/valsartan therapeutic strategy in HFpEF: Clinical insights and perspectives.[J].Mauro Gori;Emilia D'Elia;Michele Senni.International Journal of Cardiology.2018,

[2]

Sacubitril/valsartan: a cardiovascular drug with pluripotential actions [J].

Chrysant, Steven G. ;

Chrysant, George S. .

CARDIOVASCULAR DIAGNOSIS AND THERAPY, 2018, 8 (04) :543-548

[3]

Renal Effects and Associated Outcomes During Angiotensin-Neprilysin Inhibition in Heart Failure [J].

Damman, Kevin ;

Gori, Mauro ;

Claggett, Brian ;

Jhund, Pardeep S. ;

Senni, Michele ;

Lefkowitz, Martin P. ;

Prescott, Margaret F. ;

Shi, Victor C. ;

Rouleau, Jean L. ;

Swedberg, Karl ;

Zile, Michael R. ;

Packer, Milton ;

Desai, Akshay S. ;

Solomon, Scott D. ;

McMurray, John J., V .

JACC-HEART FAILURE, 2018, 6 (06) :489-498

[4]

Mortality and Readmission Following Hospitalisation for Heart Failure in Australia: A Systematic Review and Meta-Analysis [J].

Al-Omary, Mohammed S. ;

Davies, Allan J. ;

Evans, Tiffany-Jane ;

Bastian, Bruce ;

Fletcher, Peter J. ;

Attia, John ;

Boyle, Andrew J. .

HEART LUNG AND CIRCULATION, 2018, 27 (08) :917-927

[5]

Rationale and design of TRANSITION: a randomized trial of pre-discharge vs. post-discharge initiation of sacubitril/valsartan [J].

Pascual-Figal, Domingo ;

Wachter, Rolf ;

Senni, Michele ;

Belohlavek, Jan ;

Noe, Adele ;

Carr, David ;

Butylin, Dmytro .

ESC HEART FAILURE, 2018, 5 (02) :327-336

[6]

Leptin-Aldosterone-Neprilysin Axis Identification of Its Distinctive Role in the Pathogenesis of the Three Phenotypes of Heart Failure in People With Obesity [J].

Packer, Milton .

CIRCULATION, 2018, 137 (15) :1614-1631

[7]

Effects of angiotensin-neprilysin inhibition compared to angiotensin inhibition on ventricular arrhythmias in reduced ejection fraction patients under continuous remote monitoring of implantable defibrillator devices [J].

de Diego, Carlos ;

Gonzalez-Torres, Luis ;

Maria Nunez, Jose ;

Centurion Inda, Raul ;

Martin-Langerwerf, David A. ;

Sangio, Antonio D. ;

Chochowski, Piotr ;

Casasnovas, Pilar ;

Blazquez, Julio C. ;

Almendral, Jesus .

HEART RHYTHM, 2018, 15 (03) :395-402

[8]

Angiotensin Receptor Neprilysin Inhibition in Heart Failure With Preserved Ejection Fraction Rationale and Design of the PARAGON-HF Trial [J].

Solomon, Scott D. ;

Rizkala, Adel R. ;

Gong, Jianjian ;

Wang, Wenyan ;

Anand, Inder S. ;

Ge, Junbo ;

Lam, Carolyn S. P. ;

Maggioni, Aldo P. ;

Martinez, Felipe ;

Packer, Milton ;

Pfeffer, Marc A. ;

Pieske, Burkert ;

Redfield, Margaret M. ;

Rouleau, Jean L. ;

Van Veldhuisen, Dirk J. ;

Zannad, Faiez ;

Zile, Michael R. ;

Desai, Akshay S. ;

Shi, Victor C. ;

Lefkowitz, Martin P. ;

McMurray, John J. V. .

JACC-HEART FAILURE, 2017, 5 (07) :471-482

[9]

Understanding the Epidemiology of Heart Failure to Improve Management Practices: An Asia-Pacific Perspective.[J].Jeyamalar Rajadurai;Hung-Fat Tse;Chao-Hung Wang;Ning-I Yang;Jingmin Zhou;David Sim.Journal of Cardiac Failure.2017,

[10]

The effects of sacubitril/valsartan on coronary outcomes in PARADIGM-HF.[J].Ulrik M. Mogensen;Lars Køber;Søren L. Kristensen;Pardeep S. Jhund;Jianjian Gong;Martin P. Lefkowitz;Adel R. Rizkala;Jean L. Rouleau;Victor C. Shi;Karl Swedberg;Michael R. Zile;Scott D. Solomon;Milton Packer;John J.V. McMurray.American Heart Journal.2017,

← 1 2 3 →