感染后肠易激综合征研究现状

被引:6
作者
宋军
侯晓华
机构
[1] 华中科技大学同济医学院附属协和医院消化科
关键词
肠易激综合征; 感染; 发病机制; 模型,动物;
D O I
暂无
中图分类号
R574 [肠疾病];
学科分类号
1002 ; 100201 ;
摘要
肠易激综合征(IBS)是最常见的功能性胃肠病之一,已有研究证据表明其可能是多种因素共同作用的结果,包括遗传和环境因素、胃肠动力改变、内脏高敏感、肠道感染和炎症、慢性应激、肠道细菌过度生长和脑-肠轴功能紊乱等。部分患者在急性肠道感染恢复后仍存在腹痛、腹部不适、腹泻等症状,即感染后肠易激综合征(PI-IBS),是近年功能性胃肠病的研究热点。本文就PI-IBS的定义、流行病学、发病机制、动物模型、临床特征、诊断和治疗等研究现状作一概述。
引用
收藏
页码:71 / 74
页数:4
相关论文
共 14 条
[1]  
907 LX1031, a Novel Locally-Acting Inhibitor of Serotonin (5-HT) Synthesis Significantly Improves Symptoms in Patients With IBS[J] . Philip Brown,Dennis S. Riff,Jessica Jackson,Kenneth Frazier,Elaine Clark,Qi M. Yang,Wade Walke,Joel Freiman,Alan J. Main,Brian Zambrowicz,Arthur Sands.Gastroenterology . 2010 (5)
[2]   Genetic Risk Factors for Post-Infectious Irritable Bowel Syndrome Following a Waterborne Outbreak of Gastroenteritis [J].
Villani, Alexandra-Chloe ;
Lemire, Mathieu ;
Thabane, Marroon ;
Belisle, Alexandre ;
Geneau, Genevieve ;
Garg, Amit X. ;
Clark, William F. ;
Moayyedi, Paul ;
Collins, Stephen M. ;
Franchimont, Denis ;
Marshall, John K. .
GASTROENTEROLOGY, 2010, 138 (04) :1502-1513
[3]   Postinfectious Irritable Bowel Syndrome [J].
Spiller, Robin ;
Garsed, Klara .
GASTROENTEROLOGY, 2009, 136 (06) :1979-1988
[4]  
Synaptic Plasticity: The New Explanation of Visceral Hypersensitivity in Rats with Trichinella spiralis Infection?[J] . Xiaojun Yang,Lei Sheng,Yang Guan,Wei Qian,Xiaohua Hou.Digestive Diseases and Sciences . 2009 (5)
[5]  
Neuro-immune interactions in inflammatory bowel disease and irritable bowel syndrome: Future therapeutic targets[J] . Aletta D. Kraneveld,Anneke Rijnierse,Frans P. Nijkamp,Johan Garssen.European Journal of Pharmacology . 2008 (2)
[6]   A new rat model links two contemporary theories in irritable bowel syndrome [J].
Pimentel, Mark ;
Chatterjee, Soumya ;
Chang, Christopher ;
Low, Kimberly ;
Song, Yuli ;
Liu, Chengxu ;
Morales, Walter ;
Ali, Lemeesa ;
Lezcano, Sheila ;
Conklin, Jeffery ;
Finegold, Sydney .
DIGESTIVE DISEASES AND SCIENCES, 2008, 53 (04) :982-989
[7]   Cyclic AMP signaling contributes to neural plasticity and hyperexcitability in AH sensory neurons following intestinal Trichinella spiralis-induced inflammation [J].
Chen, Zhixiong ;
Suntres, Zach ;
Palmer, Jeffrey ;
Guzman, Jorge ;
Javed, Asad ;
Xue, Jianjing ;
Yu, Jun-Ge ;
Cooke, Helen ;
Awad, Hamdy ;
Hassanain, Hamdy H. ;
Cardounel, Arturo J. ;
Christofi, Fievos L. .
INTERNATIONAL JOURNAL FOR PARASITOLOGY, 2007, 37 (07) :743-761
[8]  
Hypothalamic-Pituitary-Gut Axis Dysregulation in Irritable Bowel Syndrome: Plasma Cytokines as a Potential Biomarker?[J] . Timothy G. Dinan,Eamonn M.M. Quigley,Salah M.M. Ahmed,Paul Scully,Sinead O’Brien,Liam O’Mahony,Siobhan O’Mahony,Fergus Shanahan,P.W. Napoleon Keeling.Gastroenterology . 2006 (2)
[9]   The incidence of irritable bowel syndrome among community subjects with previous acute enteric infection [J].
Borgaonkar, Mark R. ;
Ford, David C. ;
Marshall, John K. ;
Churchill, Elizabeth ;
Collins, Stephen M. .
DIGESTIVE DISEASES AND SCIENCES, 2006, 51 (05) :1026-1032
[10]  
Dyspepsia and Irritable Bowel Syndrome After a Salmonella Gastroenteritis Outbreak: One-Year Follow-up Cohort Study[J] . Gastroenterology . 2005 (1)