毛果芸香碱的抗血小板作用的探讨

被引:2
作者
储钟禄
陈正军
邹祝英
机构
[1] 第二军医大学生物化学教研室
关键词
毛果芸香碱; 血小板聚集作用; 血小板解聚作用; 血小板间桥;
D O I
10.16781/j.0258-879x.1986.03.008
中图分类号
学科分类号
摘要
在发现毛果芸香碱抗血小板聚集作用的基础上,在家兔血小板实验中进一步证明(1)毛果芸香碱有抑制腺苷二磷酸、花生四烯酸和胶原诱发血小板聚集和释放ATP的作用;对腺苷二磷酸和花生四烯酸诱发的血小板变形无抑制作用,对胶原诱发的变形则有抑制作用。(2)毛果芸香碱对腺苷二磷酸和花生四烯酸诱发的血小板聚集团有解聚作用,但对胶原诱发的则无解聚作用。Nachman等证明的血小板间桥模式不能解释此现象。我们提出了两种有糖蛋白G参与的血小板间桥模式的设想。
引用
收藏
页码:183 / 186+245 +245
页数:5
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