OPG/RANK/RANKL系统与骨折和类风湿性关节炎

被引：19

作者：

范慧洁

戴如春

廖二元

机构：

[1] 中南大学湘雅二医院代谢内分泌研究所

来源：

国际内分泌代谢杂志 | 2006年 / 04期

关键词：

骨保护素; RANK; RANKL; 骨质疏松; 骨折; 类风湿性关节炎;

D O I：

暂无

中图分类号：

R683 [骨折、骨的损伤]; R593.22 [类风湿性关节炎];

学科分类号：

100201 [内科学]; 100220 [骨科学];

摘要：

骨保护素(OPG)、细胞核因子-κB受体活化因子(RANK)和RANK配体(RANKL)是偶联成骨细胞、基质细胞和破骨细胞分化、活化及生物活性的3种主要细胞因子,其形成的局部调节体系在骨代谢中起十分重要的作用。本文简要介绍了OPG/RANK/RANKL系统及该系统在骨质疏松性骨折发生中的作用,RANKL/OPG比值与骨折的关系,OPG和RANKL对骨折愈合的作用,血清OPG或RAN-KL水平与骨折的联系,OPG基因多态性与骨折关系的研究结果。另外还介绍其在类风湿性关节炎发病机制中的作用,OPG/RANK/RANKL与滑膜组织的联系,OPG治疗的相关实验进展。

引用

收藏

页码：241 / 244

页数：4

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