一氧化氮介导麻醉大鼠人参皂苷Rg1诱发长时程增强（英文）

被引：10

作者：

王晓英

张均田

机构：

[1] 中国医学科学院中国协和医科大学药物研究所药理研究室

[2] 中国医学科学院中国协和医科大学药物研究所药理研究室北京

[3] 中国

[4] 北京

[5] 中国

来源：

ActaPharmacologicaSinica | 2001年 / 12期

关键词：

人参; 皂苷类; 长时程增强; 突触传递; 一氧化氮; 吲唑类; 海马; 齿状回; 精氨酸;

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

摘要：

目的:研究人参皂苷Rg1对麻醉大鼠突触传递效能的影响及作用机制。方法:应用细胞外微电极记录技术,记录麻醉大鼠海马齿状回颗粒细胞群体峰电位（PS）。结果:Rg1（10,100nmol/L）提高麻醉大鼠的基础突触传递,诱导海马齿状回突触传递长时程增强（LTP）,并提高高频刺激所诱导的LTP。选择性NOS抑制剂7-硝基吲唑（7-NI,5nmol）侧脑室注射可明显抑Rg1所诱导的齿状回LTP,对基础突触传递无明显影响。L-Arg（250mg/kg,ip）可拮抗7-NI对Rg1诱导LTP的抑制作用（P<0.05）。结论:Rg1显著促进麻醉大鼠的突触传递效能,由神经元型NOS（nNOS）所产生的NO参与了Rg1对齿状回LTP的诱导过程。

引用

页码：45 / 48

页数：4

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