TRIM59、Akt及MMP-9在肝癌组织中的表达及其临床意义

被引：4

作者：

夏修良 ^{[1
]}

薛栋 ^{[1
]}

相亭海 ^{[1
]}

宋德坤 ^{[1
]}

王建强 ^{[1
]}

李新军 ^{[2
]}

机构：

[1] 山东省滨州市人民医院普外一科

[2] 山东省滨州市人民医院病理科

来源：

中国现代普通外科进展 | 2018年 / 21卷 / 08期

关键词：

肝细胞癌; 三结构域蛋白59; 蛋白激酶B; 基质金属蛋白酶-9; 免疫组织化学;

D O I：

暂无

中图分类号：

R735.7 [肝肿瘤];

学科分类号：

100214 ;

摘要：

目的 :探讨三结构域蛋白59(TRIM59)、蛋白激酶B(Akt)和基质金属蛋白酶-9(MMP-9)在肝细胞肝癌中的表达相关性及预后评价。方法:应用免疫组织化学方法回顾性分析TRIM59、Akt及MMP-9蛋白在98例肝癌组织中的表达状况,并分析各指标与临床病理参数之间的关系,应用Spearman等级检验分析TRIM59与Akt、MMP-9的相关性。结果:肝癌组织中TRIM59、Akt及MMP-9蛋白阳性表达率分别是73.5%、65.3%、61.2%,均明显高于癌旁肝组织(P<0.05)。研究发现TRIM59、Akt及MMP-9蛋白表达与病理分级、包膜完整、肿瘤分化、血管侵犯和TNM分期明显相关(P均<0.05)。肝癌组织中TRIM59与Akt、MMP-9表达均呈正相关(P<0.05),Akt和MMP-9表达也呈正相关(P<0.05)。生存分析表明,TRIM59可作为肝癌预后的一个独立性因素。结论:TRIM59、Akt和MMP-9在肝癌组织中明显高表达。TRIM59过表达与肝癌恶性进展和患者预后密切相关,提示TRIM59是肝癌患者的潜在治疗靶点。

引用

页码：599 / 602

页数：4

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