BDNF-TrkB信号通路与焦虑障碍的产生

被引：14

作者：

林玉 ^{[1
]}

张瑞桐 ^{[1
]}

兰明 ^{[1
]}

张天娥 ^{[2
]}

闫智勇 ^{[1
]}

机构：

[1] 西南交通大学生命科学与工程学院

[2] 成都中医药大学基础医学院

来源：

生命的化学 | 2013年 / 33卷 / 06期

关键词：

脑源性神经营养因子; 酪氨酸激酶受体B; 信号通路; 焦虑障碍;

D O I：

10.13488/j.smhx.2013.06.007

中图分类号：

R749.7 [神经官能症];

学科分类号：

100204 [神经病学];

摘要：

BDNF-TrkB信号通路对情绪产生、认知功能和记忆能力都有重要的影响,主要通过PI3-K途径和Ras-MAP激酶途径调节神经元的再生、凋亡及重建。近年来的研究表明,BDNF基因型及其表达量和TrkB受体表达的异常与焦虑障碍的产生有非常密切的关系。本文综述了近年来BDNF-TrkB信号通路及其与焦虑障碍产生的联系等方面的研究进展。

引用

页码：668 / 672

页数：5

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