亚低温治疗对重型脑创伤脑组织糖代谢及甘油的影响

被引：14

作者：

李爱林

只达石

张赛

黄慧玲

张国斌

莫丽冬

机构：

[1] 天津市环湖医院神经外科

来源：

中华创伤杂志 | 2005年 / 04期

关键词：

脑损伤; 微透析; 能量代谢; 甘油; 低温;

D O I：

暂无

中图分类号：

R651.15 [];

学科分类号：

摘要：

目的研究亚低温对重型脑创伤患者脑组织糖代谢及甘油的影响。方法33例患者随机分为亚低温组和常温组,将微透析探针分别置入病损周边区、病灶对侧的相应位置及腹部皮下脂肪组织,分析亚低温组及常温组脑细胞间液(extracellular fluid,ECF)的乳酸/丙酮酸(lactate/pyruvate,L/P)、乳酸/葡萄糖(lactate/glucose,L/G)及甘油(glycerol,Gly)浓度。结果亚低温组比常温组“正常区”脑ECF的L/P有明显降低;亚低温组比常温组病损周边区甘油、L/G及L/P有明显降低;常温组病损周边区比“正常区”的甘油、L/G及L/P明显增高;亚低温组病损周边区L/P比“正常区”有明显增高。结论亚低温治疗可能通过降低病损周边区脑ECF中L/P、L/G及甘油的浓度及“正常区”L/P的浓度而发挥脑保护作用;颅脑创伤后病损周边区更易发生能量代谢紊乱及细胞膜降解,亚低温对这一区域有显著保护作用。

引用

页码：241 / 243

页数：3

共 11 条

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