噻唑烷二酮类药物对心血管相关危险因素的影响

被引：5

作者：

郑仁东

任安

机构：

[1] 安徽医科大学附属省立医院内分泌科

来源：

国外医学(老年医学分册) | 2008年 / 02期

关键词：

噻唑烷二酮:过氧化物酶体增殖物激活受体-γ; 动脉粥样硬化:水肿:心力衰竭;

D O I：

暂无

中图分类号：

R54 [心脏、血管（循环系）疾病];

学科分类号：

摘要：

噻唑烷二酮类药物作为过氧化物酶体增殖物激活受体-γ激动剂,能够增加胰岛素敏感性,减轻胰岛素抵抗,有着显著的降糖作用。越来越多的证据表明,噻唑烷二酮对心血管系统也发挥着影响。一方面,在调节血压,血脂代谢,氧化应激,抗炎,纤溶活性与抗凝等方面对心血管起到保护作用。另一方面,在增加体重,导致水肿和水钠潴留以及加重心衰等方面对心血管产生不利的影响。本文就噻唑烷二酮对心血管系统的影响做一综述。

引用

页码：71 / 75

页数：5

共 11 条

[1] A randomized trial of the effects of rosiglitazone and metformin on inflammation and subclinical atherosclerosis in patients with type 2 diabetes [J].

Stocker, Derek J. ;

Taylor, Allen J. ;

Langley, Roy W. ;

Jezior, Mattliew R. ;

Vigersky, Robert A. .

AMERICAN HEART JOURNAL, 2007, 153 (03) :445.e1-445.e6

[2] Thiazolidinediones in patients with type 2 diabetes mellitus and heart failure [J].

Granberry, Mark C. ;

Hawkins, Jason B. ;

Franks, Amy M. .

AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY, 2007, 64 (09) :931-936

[3] Effects of peroxisome proliferator-activated receptor (PPAR)-α and PPAR-γ agonists on glucose and lipid metabolism in patients with type 2 diabetes mellitus [J].

Bajaj, M. ;

Suraamornkul, S. ;

Hardies, L. J. ;

Glass, L. ;

Musi, N. ;

DeFronzo, R. A. .

DIABETOLOGIA, 2007, 50 (08) :1723-1731

[4]

Vascular effects of TZDs: New implications[J] . Florian Blaschke,Robert Spanheimer,Mehmood Khan,Ronald E. Law.Vascular Pharmacology . 2006 (1)

[5]

Peroxisome Proliferator-Activated Receptor Gamma Agonists: Their Role as Vasoprotective Agents in Diabetes[J] . Florian Blaschke,Evren Caglayan,Willa A. Hsueh.Endocrinology and Metabolism Clinics of North America . 2006 (3)

[6] Effect of troglitazone on serum γ-glutamyltransferase activity and plasma t-PA/PAI-1 complex in type 2 diabetic patients [J].

Koh, H ;

Akiyama, Y ;

Yui, K .

ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, 2006, 56 (04) :288-294

[7]

Angiopoietin-like proteins: potential new targets for metabolic syndrome therapy[J] . Yuichi Oike,Masaki Akao,Yoshiaki Kubota,Toshio Suda.Trends in Molecular Medicine . 2005 (10)

[8] Ambulatory blood pressure reduction after rosiglitazone treatment in patients with type 2 diabetes and hypertension correlates with insulin sensitivity increase [J].

Sarafidis, PA ;

Lasaridis, AN ;

Nilsson, PM ;

Pagkalos, EM ;

Hitoglou-Makedou, AD ;

Pliakos, CI ;

Kazakos, KA ;

Yovos, JG ;

Zebekakis, PE ;

Tziolas, IM ;

Tourkantonis, AN .

JOURNAL OF HYPERTENSION, 2004, 22 (09) :1769-1777

[9]

Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes .2 Nissen SE,Wolski K. NEngl J Med . 2007

[10]

Collecting duct-specific deletion of peroxisome proliferator-activated receptor gamma blocks thiazolidinedione-induced fluid retention .2 Zhang H,Zhang A,Kohan DE,et al. Proc Natl Acad Sci U S A . 2005

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